Doramapimod
Cat. No. :YN350026
CAS No. :285983-48-4
86-020-82000279
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order@ubiochem.com| Product Name: | Doramapimod |
| CAS NO.: | 285983-48-4 |
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| Molecular Weight: | 527.66 |
| Molecular Formula: | C₃₁H₃₇N₅O₃ |
| SMILES: | O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Doramapimod (BIRB 796) is a pan-p38 MAPK inhibitor with IC50 of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2. |
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