CL2A-SN-38
Cat. No. :YN260089
CAS No. :1279680-68-0
86-020-82000279
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order@ubiochem.com| Product Name: | CL2A-SN-38 |
| CAS NO.: | 1279680-68-0 |
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| Molecular Weight: | 1480.61 |
| Molecular Formula: | C₇₃H₉₇N₁₁O₂₂ |
| SMILES: | O=C(O[C@](C1=C(CO2)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C1)=O)(CC)C2=O)OCC6=CC=C(NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CN9C(C=CC9=O)=O)CC8)=O)=C7)=O)=O)=O)C=C6 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | CL2A-SN-38 is adrug-linker conjugatecomposed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to byst and er effect, and binds the antibody at a cysteine residue via a disulfide bond. |
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