GNF362
Cat. No. :YN371078
CAS No. :1003019-41-7
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order@ubiochem.com| Product Name: | GNF362 |
| CAS NO.: | 1003019-41-7 |
| Chemical Name: | |
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| Molecular Weight: | 426.44 |
| Molecular Formula: | C₂₂H₂₁F₃N₆ |
| SMILES: | N#CC1=CC=C(C=C1)C2=C(C=NN2)CN3C[C@H](N(CC3)C4=NC=C(C=C4)C(F)(F)F)C |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | GNF362 is a selective, potent, and orally bioavailable inhibitor ofinositol trisphosphate 3’ kinase B (Itpkb)with an IC50 of 9nM. GNF362 also inhibits Itpka and Itpkc with IC50 values of 20nM and 19nM, respectively. Inositol trisphosphate 3’ kinase B (Itpkb) is a Ca2+-dependent kinase, which phosphorylates the 3’ position of Ins (1,4,5) P3 to generate inositol 1,3,4,5-tetrakisphosphate [Ins (1,3,4,5) P4]. |
| IC50&Target: | |
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