Gliotoxin
Cat. No. :YN251702
CAS No. :67-99-2
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order@ubiochem.com| Product Name: | Gliotoxin |
| CAS NO.: | 67-99-2 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 326.39 |
| Molecular Formula: | C₁₃H₁₄N₂O₄S₂ |
| SMILES: | O=C1N(C)[C@@]2(CO)C(N3[C@@]1(SS2)CC4=CC=C[C@H](O)[C@@]34[H])=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted byA. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells. Gliotoxin inhibits inducibleNF-κBactivity by preventing IκB degradation, which consequently induces host-cellapoptosis. Gliotoxin activatesPKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitateA. fumigatusinternalization into lung epithelial cells. |
| IC50&Target: | |
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