BAY 61-3606
Cat. No. :YN440413
CAS No. :732983-37-8
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order@ubiochem.com| Product Name: | BAY 61-3606 |
| CAS NO.: | 732983-37-8 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 390.40 |
| Molecular Formula: | C₂₀H₁₈N₆O₃ |
| SMILES: | O=C(C1=CC=CN=C1NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | BAY 61-3606 is an orally available, ATP-competitive, reversible and highly selectiveSykinhibitor with a Ki of 7.5nM and an IC50 of 10nM. BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells. |
| IC50&Target: | |
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