DS-437
Cat. No. :YN310173
CAS No. :1674364-87-4
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order@ubiochem.com| Product Name: | DS-437 |
| CAS NO.: | 1674364-87-4 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 397.45 |
| Molecular Formula: | C₁₅H₂₃N₇O₄S |
| SMILES: | O[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@H]3CSCCNC(NCC)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | DS-437 is a dualPRMT5/7inhibitor (IC50s of PRMT5/7=6μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC50s of 52 and 62μM, respectively. DS-437 inhibits the methylation of FOXP3. |
| IC50&Target: | |
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| References: |
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