Phellodendrine
Cat. No. :YN410102
CAS No. :6873-13-8
86-020-82000279
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order@ubiochem.com| Product Name: | Phellodendrine |
| CAS NO.: | 6873-13-8 |
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| Molecular Weight: | 342.41 |
| Molecular Formula: | C₂₀H₂₄NO₄ |
| SMILES: | OC1=C(OC)C=C2CC[N@@+]3(C)CC4=CC(OC)=C(O)C=C4C[C@@]3([H])C2=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Phellodendrine can suppress local semisyngeneic GvH reactions and systemic allogeneic GvH reactions in X-ray irradiated recipient mice, it also can suppress the induction phase of sheep red blood cell (SRBC)-induced delayed type hypersensitivity in mice and tuberculin-induced delayed type hypersensitivity in guinea pigs, suggests that phellodendrine is expected to be a valuable new type of immunosuppressor against the cellular immune response. Phellodendrine has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. Phellodendrine shows a good antioxidant effect in vivo, it can down-regulating AKT, IKK, NF-kB phosphorylation and COX-2 expression induced by AAPH, it also ameliorates the ROS-mediated inflammatory response. Phellodendrine can reduce blood pressure and has antinephritis activity. |
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