NF157
Cat. No. :YN320377
CAS No. :104869-26-3
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order@ubiochem.com| Product Name: | NF157 |
| CAS NO.: | 104869-26-3 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 1437.10 |
| Molecular Formula: | C₄₉H₂₈F₂N₆Na₆O₂₃S₆ |
| SMILES: | O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2F)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6F)=O)=CC=C5 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | NF157 is a highly selective nanomolarP2Y11antagonist with a pKi of 7.35. TheIC50s are 463nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA). |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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