Boldine
Cat. No. :YN483467
CAS No. :476-70-0
86-020-82000279
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order@ubiochem.com| Product Name: | Boldine |
| CAS NO.: | 476-70-0 |
| Chemical Name: | |
| Synonyms: | 1,10-Dimethoxy-2,9-dihydroxyaporphine; ex Peumus boldus |
| Molecular Weight: | 327.37 |
| Molecular Formula: | C₁₉H₂₁NO₄ |
| SMILES: | OC1=C(OC)C2=C3C(CCN(C)[C@@]3([H])CC4=CC(O)=C(OC)C=C24)=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Boldine can stimulate the Bsep transcriptional regulator, FXR receptor. Boldine has anti-cancer activity, can treat urinary bladder cancer and as a candidate for telomerase-targeted cancer care. Boldine displays cytoprotective , anti-oxidant and anti-inflammatory activities, which may arise from its free radical scavenging properties; it prevents the increase in lipoperoxidation levels induced by ischemia, but higher concentrations potentiated this parameter. Boldine reduces oxidative stress and improves endothelium-dependent relaxation in aortas of diabetic mice largely through inhibiting ROS overproduction associated with Ang II-mediated BMP4-dependent mechanisms. Boldine may attenuate the catecholamine oxidation-induced brain mitochondrial dysfunction and decrease the dopamine-induced death of PC12 cells through a scavenging action on reactive oxygen species and inhibition of melanin formation and thiol oxidation. |
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