Alosetron ((Z)-2-butenedioate)
Cat. No. :YN321296
CAS No. :122852-43-1
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order@ubiochem.com| Product Name: | Alosetron ((Z)-2-butenedioate) |
| CAS NO.: | 122852-43-1 |
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| Molecular Weight: | 410.42 |
| Molecular Formula: | C₂₁H₂₂N₄O₅ |
| SMILES: | O=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C.O=C(/C=CC(O)=O)O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin5-HT3 receptorantagonist. Alosetron (Z)-2-butenedioate is used for the research of irritable bowel syndrome (IBS). Alosetron (Z)-2-butenedioate blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50at ~55nM. Alosetron (Z)-2-butenedioate attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects. |
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