THIQ
Cat. No. :YN320300
CAS No. :312637-48-2
86-020-82000279
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order@ubiochem.com| Product Name: | THIQ |
| CAS NO.: | 312637-48-2 |
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| Molecular Weight: | 589.17 |
| Molecular Formula: | C₃₃H₄₁ClN₆O₂ |
| SMILES: | ClC1=CC=C(C=C1)C[C@@H](NC([C@@H]2NCC3=CC=CC=C3C2)=O)C(N4CCC(C5CCCCC5)(CN6C=NC=N6)CC4)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | THIQ is the first selective agonist of themelanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2nM,EC50=2.1nM) and rMC4R (IC50=0.6nM,EC50=2.9nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants. |
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