AY 9944
Cat. No. :YN480327
CAS No. :366-93-8
86-020-82000279
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order@ubiochem.com| Product Name: | AY 9944 |
| CAS NO.: | 366-93-8 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 464.30 |
| Molecular Formula: | C₂₂H₃₀Cl₄N₂ |
| SMILES: | ClC(C=CC=C1)=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C=CC=C3)Cl.[H]Cl.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | AY 9944 is a specificcholesterol biosynthesisinhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol . |
| IC50&Target: | |
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