GNF4877
Cat. No. :YN420145
CAS No. :2041073-22-5
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order@ubiochem.com| Product Name: | GNF4877 |
| CAS NO.: | 2041073-22-5 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 494.52 |
| Molecular Formula: | C₂₅H₂₇FN₆O₄ |
| SMILES: | O=C([C@H]1CN(C2=C(NC(C3=NC(C4=CC(OC(C)C)=CC=C4F)=CN=C3N)=O)C=NC=C2)CCC1)O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | GNF4877 is a potentDYRK1A and GSK3βinhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50of 0.66 μM for mouse β (R7T1) cells). |
| IC50&Target: | |
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| In Vivo: | |
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