DBPR108
Cat. No. :YN371022
CAS No. :1186426-66-3
86-020-82000279
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order@ubiochem.com| Product Name: | DBPR108 |
| CAS NO.: | 1186426-66-3 |
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| Molecular Weight: | 324.39 |
| Molecular Formula: | C₁₆H₂₅FN₄O₂ |
| SMILES: | N#C[C@H]1N(C(CNC(C)(C)CC(N2CCCC2)=O)=O)C[C@@H](F)C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15nM; no inhibition on DDP8 and DPP9. DBPR108 is an IC50=15nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus. |
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