Tat-NR2B9c TFA
Cat. No. :YN330658
CAS No. :1834571-04-8
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order@ubiochem.com| Product Name: | Tat-NR2B9c TFA |
| CAS NO.: | 1834571-04-8 |
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| Molecular Weight: | 2632.90 |
| Molecular Formula: | C₁₀₅H₁₈₈N₄₂O₃₀.C₂HF₃O₂ |
| SMILES: | [YGRKKRRQRRRKLSSIESDV (TFA salt)] |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, withEC50values of 6.7nM and 670nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5μM and 8μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy. |
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