(R)-CR8 trihydrochloride
Cat. No. :YN270366
CAS No. :1786438-30-9
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order@ubiochem.com| Product Name: | (R)-CR8 trihydrochloride |
| CAS NO.: | 1786438-30-9 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 540.92 |
| Molecular Formula: | C₂₄H₃₂Cl₃N₇O |
| SMILES: | CC[C@@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO.Cl.Cl.Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | (R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potentCDK1/2/5/7/9inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09μM), CDK2/cyclin A (0.072μM), CDK2/cyclin E (0.041μM), CDK5/p25 (0.11μM), CDK7/cyclin H (1.1μM), CDK9/cyclin T (0.18μM) and CK1δ/ε (0.4μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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