A 839977
Cat. No. :YN360469
CAS No. :870061-27-1
86-020-82000279
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order@ubiochem.com| Product Name: | A 839977 |
| CAS NO.: | 870061-27-1 |
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| Molecular Weight: | 413.26 |
| Molecular Formula: | C₁₉H₁₄Cl₂N₆O |
| SMILES: | ClC1=C(Cl)C(N2N=NN=C2NCC3=CC=CC=C3OC4=NC=CC=C4)=CC=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | A 839977 is aP2X7selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20nM, 42nM and 150nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta. |
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