NS8593 hydrochloride
Cat. No. :YN360240
CAS No. :875755-24-1
86-020-82000279
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order@ubiochem.com| Product Name: | NS8593 hydrochloride |
| CAS NO.: | 875755-24-1 |
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| Molecular Weight: | 299.80 |
| Molecular Formula: | C₁₇H₁₈ClN₃ |
| SMILES: | [H]Cl.C1(N[C@@H]2CCCC3=C2C=CC=C3)=NC4=CC=CC=C4N1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | NS8593 hydrochloride is a potent and selectivesmall conductance Ca2+-activated K+channels (SK channels)inhibitor. NS8593 hydrochloride reversibly inhibitsSK3-mediated currents with aKdvalue of 77nM. NS8593 hydrochloride inhibits all theSK1-3subtypes Ca2+-dependently (Kds of 0.42, 0.60, and 0.73μM, respectively, at 0.5μM Ca2+), and does not affect the Ca2+-activated K+channels of intermediate and large conductance (hIK and hBK channels, respectively). |
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