DL-TBOA
Cat. No. :YN360185
CAS No. :205309-81-5
86-020-82000279
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order@ubiochem.com| Product Name: | DL-TBOA |
| CAS NO.: | 205309-81-5 |
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| Molecular Weight: | 239.22 |
| Molecular Formula: | C₁₁H₁₃NO₅ |
| SMILES: | OC([C@@H](N)[C@@H](C(O)=O)OCC1=CC=CC=C1)=O.[Relative stereochemistry] |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70μM, 6μM and 6μM forexcitatory amino acid transporter-1 (EAAT1),EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the humanEAAT1 and EAAT2with Ki valuesof 42μM and 5.7μM, respectively. DL-TBOA blocksEAAT4 and EAAT5in a competitive manner with Ki values of 4.4μM and 3.2μM, respectively . |
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