JNJ-61432059
Cat. No. :YN360268
CAS No. :2035814-50-5
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order@ubiochem.com| Product Name: | JNJ-61432059 |
| CAS NO.: | 2035814-50-5 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 443.47 |
| Molecular Formula: | C₂₅H₂₂FN₅O₂ |
| SMILES: | OC1CCN(C2=NC=CC3=C(C4=CC=C(NC(C5)=O)C5=C4)C(C6=CC=C(F)C=C6)=NN32)CC1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | JNJ-61432059 is an oral active and selective negative modulator ofAMPARassociated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with apIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. |
| IC50&Target: | |
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