Nardosinone
Cat. No. :YN482435
CAS No. :23720-80-1
86-020-82000279
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order@ubiochem.com| Product Name: | Nardosinone |
| CAS NO.: | 23720-80-1 |
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| Molecular Weight: | 250.33 |
| Molecular Formula: | C₁₅H₂₂O₃ |
| SMILES: | O=C1C[C@@]2([H])OOC(C)(C)[C@@]2([H])[C@@]3(C)[C@H](C)CCC=C13 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC. |
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