Diclofensine hydrochloride
Cat. No. :YN1730078
CAS No. :34041-84-4
86-020-82000279
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order@ubiochem.com| Product Name: | Diclofensine hydrochloride |
| CAS NO.: | 34041-84-4 |
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| Molecular Weight: | 358.69 |
| Molecular Formula: | C₁₇H₁₈Cl₃NO |
| SMILES: | CN1CC2=C(C=CC(OC)=C2)C(C3=CC=C(Cl)C(Cl)=C3)C1.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7nM, respectively. The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake . Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM). On the other h and , diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release . |
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