Methoxy-PEPy
Cat. No. :YN320604
CAS No. :524924-76-3
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order@ubiochem.com| Product Name: | Methoxy-PEPy |
| CAS NO.: | 524924-76-3 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 210.23 |
| Molecular Formula: | C₁₃H₁₀N₂O |
| SMILES: | COC1=CC(C#CC2=NC=CC=C2)=CN=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1nM. Administration of [3H]methoxy-PEPy (50 microCi/kg i.v.) to mGlu5 receptor-deficient mice revealed binding at background levels in forebrain, whereas wild-type mice exhibited 14-fold higher binding in forebrain relative to cerebellum . The calcium transients stimulated by these agonists were potently inhibited by reference allosteric mGlu5 antagonists - 2-methyl-6-(phenylethynyl)pyridine (MPEP), 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and 3-methoxy-5-(pyridine-2-ylethynyl)pyridine (methoxy-PEPy) (IC(50) ranges: 0.8-66nM) . |
| IC50&Target: | |
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| References: |
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