HQ-415
Cat. No. :YN481637
CAS No. :430462-93-4
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order@ubiochem.com| Product Name: | HQ-415 |
| CAS NO.: | 430462-93-4 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 415.48 |
| Molecular Formula: | C₂₅H₂₅N₃O₃ |
| SMILES: | OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(OC)C(OCC)=C3)NC4=NC=CC(C)=C4 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ-415 is 15μM. IC50 value: 15μM (EC50) in vitro: In TDP-43-expressing cells, CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5μM. HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 are retested in dose for their ability to rescue TDP-43. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14μM. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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