D-α-Hydroxyglutaric acid
Cat. No. :YN330131
CAS No. :13095-47-1
86-020-82000279
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order@ubiochem.com| Product Name: | D-α-Hydroxyglutaric acid |
| CAS NO.: | 13095-47-1 |
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| Molecular Weight: | 148.11 |
| Molecular Formula: | C₅H₈O₅ |
| SMILES: | O=C(O)[C@H](O)CCC(O)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | D-α-Hydroxyglutaric acid ((R)-2-Hydroxypentanedioic acid) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist ofα-ketoglutarate (α-KG) and inhibits multipleα-KG-dependent dioxygenaseswith a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increasesreactive oxygen species (ROS)production. D-α-Hydroxyglutaric acid binds and inhibitsATP synthase and inhibitsmTORsignaling . |
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