AMN082
Cat. No. :YN320267
CAS No. :97075-46-2
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Product Name: | AMN082 |
CAS NO.: | 97075-46-2 |
Chemical Name: | |
Synonyms: | |
Molecular Weight: | 465.46 |
Molecular Formula: | C₂₈H₃₀Cl₂N₂ |
SMILES: | [H]Cl.[H]Cl.C(NCCNC(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4 |
Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
Transportation: | Room temperature in continental US; may vary elsewhere. |
Description: | AMN082, a selective, orally active, and brain penetrantmGluR7agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50values, 64-290nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects. |
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