YN350233 Rhoifolin

Rhoifolin is a flavone glycoside isolated fromCitrus gr and is(L.) Osbeck leaves. Rhoifolin is beneficial for diabetic complications through enhanced adiponectin secretion, tyrosine phosphorylation ofinsulin receptor-β and glucose tra...

YN350233 Rhoifolin 17306-46-6

Rhoifolin is a flavone glycoside isolated fromCitrus gr and is(L.) Osbeck leaves. Rhoifolin is beneficial for diabetic complications through enhanced adiponectin secretion, tyrosine phosphorylation ofinsulin receptor-β and glucose tra...

YN350133 CKI-7 free base 120615-25-0

CKI-7 free base is a potent and ATP-competitivecasein kinase 1 (CK1)inhibitor with an IC50 of 6μM and a Ki of 8.5μM. CKI-7 free base is a selectiveCdc7 kinaseinhibitor. CKI-7 free base also inhibitsSGK,ribosomal...

YN350065 AZ 628 878739-06-1

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.

YN321677 Pregnenolone monosulfate 1247-64-9

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor ofc...

YN321395 Pregnenolone 145-13-1

Pregnenolone is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.

YN320342 Methiothepin mesylate 74611-28-2

Methiothepin mesylate is a potent and non-selective5-HT2receptorantagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and...

YN350104 BRD7389 376382-11-5

BRD7389 is a specificRSKfamily kinase inhibitor with IC50s of 1.5μM, 2.4μM, and 1.2μM forRSK1,RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells.

YN320466 N-Oleoyl glycine 2601-90-3

N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation ofCB1 receptor and Aktsignaling pathway in 3T3-L1 adipocyte.

YN321736 Yangonin 500-62-9

Yangonin is a novel CB₁ receptor ligand, it exhibits affinity for the human recombinant CB₁ receptor. Yangonin could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation. ...

YN320375 Anandamide 94421-68-8

An and amide is an immune modulator in the central nervous system acts via not onlycannabinoid receptors(CB1 and CB2) but also other targets (e.g.,GPR18/GPR55).

YN321194 JD-5037 1392116-14-1

JD-5037 is a peripherally restricted (PR) cannabinoid-1 receptor blocker with an IC50 value of 2 nM for CB1 receptor and > 1000 nM for CB2 receptor.

YN320273 AH 6809 33458-93-4

AH 6809 is an antagonist ofEP and DP receptor, with a Ki of 1217, 1150, 1597, and 1415nM for the clonedhuman EP1,EP2,EP3-III, and DP receptorrespectively, and with a Ki of 350nM formouse EP2receptor .

YN320981 RS 504393 300816-15-3

RS 504393 is a selectiveCCR2chemokine receptor antagonist (IC50 values are 89nM and > 100μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).

YN250581 Rimonabant Hydrochloride 158681-13-1

Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective centralcannabinoid receptor (CB1)antagonist with an Ki of 1.8nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibitsMycob...