YN330689 Pamicogrel 101001-34-7

Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregatory properties.

YN320420 VUF11207 fumarate 1785665-61-3

VUF11207 fumarate (Compound 29) is aCXCR7agonist and a high-potencyCXCR7(pKiof 8.1) lig and that induces recruitment ofβ-arrestin2(pEC50of 8.8) and subsequent internalization (pEC50of 7.9) ofCXCR7.

YN350095 SP600125 129-56-6

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MK...

YN321524 Amitriptyline hydrochloride 549-18-8

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.

YN330651 γ-Tocopherol 54-28-4

γ-Tocopherol (D-γ-Tocopherol) is a potentcyclooxygenase (COX)inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory prop...

YN321282 SB-265610 211096-49-0

SB-265610 is a selective, competitive, nonpeptide and allostericCXCR2antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis with IC50s...

YN350234 Isovitexin 38953-85-4

Isovitexin is a flavonoid isolated from rice hulls ofOryza sativa, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like aJNK1/2inhibitor and inhibits the activation ofNF-κB.

YN251589 Rhapontigenin 500-65-2

In vitro inhibitory concentration against proliferation of HL60 cells

YN320349 CXCR7 modulator 1 2231812-31-8

CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybridCXCR7modulator, with a Ki of 9nM.

YN320682 SRT3190 1204707-73-2

SRT3190 is an antagonist ofCXCR2, used in the research of chemokine mediated diseases.

YN320097 CXCR2-IN-1 1873376-49-8

CXCR2-IN-1 is a central nervous system penetrantCXCR2antagonists with apIC50 of 9.3.

YN320843 Cimetidine 51481-61-9

Cimetidine, a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

YN320951 Reparixin L-lysine salt 266359-93-7

Reparixin L-lysine salt is an allosteric inhibitor ofchemokine receptor 1/2 (CXCR1/2)activation.

YN321703 Baohuoside I 113558-15-9

Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.

YN320950 Reparixin 266359-83-5

Reparixin(Repertaxin) is a inhibitor of human CXCR1/R2 and rat CXCR2 receptor activation. It also inhibits human CXCL8 receptor activation.