YN350229 Corynoxeine 630-94-4

Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC ...

YN350250 Methylnissolin 73340-41-7

Methylnissolin (Astrapterocarpan), isolated fromAstragalus membranaceus, inhibitsplatelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10μM. Methylnissolin inhibits PDGF-BB-induced phosphory...

YN350173 Ravoxertinib 1453848-26-4

Ravoxertinib (GDC-0994) is an orally bioavailableERKkinase inhibitor with an IC50 of 6.1nM and 3.1nM forERK1 and ERK2, respectively.

YN350219 Honokiol 35354-74-6

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

YN350174 Ravoxertinib hydrochloride 2070009-58-2

Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective forERKkinase activity with IC50 of 6.1nM and 3.1nM forERK1 and ERK2, respectively.

YN340274 Mogrol 88930-15-8

Mogrol is a biometabolite of mogrosides, and acts via inhibition of theERK1/2 and STAT3pathways, or reducingCREBactivation and activatingAMPKsignaling.

YN330168 PD98059 167869-21-8

PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK does not directly inhibit ERK1 or ERK2.

YN350047 Pluripotin 839707-37-8

Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP with Kd values of 98 nM and 212 nM respectively. It maintains embryonic stem cell (ESC) self-renewal.

YN350237 Magnolin 31008-18-1

Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.

YN350107 FR 180204 865362-74-9

FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK...

YN251592 Piperlongumine 20069-09-4

Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a...

YN350228 Astragaloside IV 84687-43-4

Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous syst...