YN350229 Corynoxeine 630-94-4

Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC ...

YN350250 Methylnissolin 73340-41-7

Methylnissolin (Astrapterocarpan), isolated fromAstragalus membranaceus, inhibitsplatelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10μM. Methylnissolin inhibits PDGF-BB-induced phosphory...

YN350173 Ravoxertinib 1453848-26-4

Ravoxertinib (GDC-0994) is an orally bioavailableERKkinase inhibitor with an IC50 of 6.1nM and 3.1nM forERK1 and ERK2, respectively.

YN350219 Honokiol 35354-74-6

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

YN350174 Ravoxertinib hydrochloride 2070009-58-2

Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective forERKkinase activity with IC50 of 6.1nM and 3.1nM forERK1 and ERK2, respectively.

YN350190 DEL-22379 181223-80-3

DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ?0.5 μM.

YN340274 Mogrol 88930-15-8

Mogrol is a biometabolite of mogrosides, and acts via inhibition of theERK1/2 and STAT3pathways, or reducingCREBactivation and activatingAMPKsignaling.

YN350142 VX-11e 896720-20-0

VX-11e is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.

YN350237 Magnolin 31008-18-1

Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.

YN350055 AG126 118409-62-4

AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.

YN350107 FR 180204 865362-74-9

FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK...

YN251592 Piperlongumine 20069-09-4

Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a...