YN340120 Gandotinib

Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.

YN340120 Gandotinib 1229236-86-5

Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.

YN360003 BAY-876 1799753-84-6

BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4.

YN350227 Pachymic acid 29070-92-6

Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibitsAkt and ERKsignaling pathways.

YN350201 trans-Zeatin 1637-39-4

Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.

YN321542 Latanoprost 130209-82-4

Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.

YN360705 Ca2+ channel agonist 1 1402821-24-2

Ca2+channel agonist 1 is an agonist ofN-type Ca2+channel and an inhibitor of CDK2, with EC50s of 14.23μM and 3.34μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

YN360936 Ginsenoside Rf 52286-58-5

Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibitsN-type Ca2+channel.

YN320823 Cisapride 81098-60-4

Cisapride is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.

YN350218 Lidocaine hydrochloride 73-78-9

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.

YN310017 AGK2 304896-28-4

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

YN373277 Palmitelaidic Acid 10030-73-6

Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

YN330638 Cafestol 469-83-0

Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is aERKinhibitor for AP-1-targeted activity againstPGE2production and the mRNA expression ofcyclooxygenase (COX)-2in LPS-act...

YN350217 Lidocaine 137-58-6

Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

YN350178 Omtriptolide 195883-06-8

Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.