YN372500 ML346 100872-83-1

ML346 is an activator ofHsp70 expression and HSF-1 activity, with an EC50 of 4.6μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 ind...

YN370192 TRC051384 867164-40-7

TRC051384 is a heat shock protein 70 (HSP70) inducer.

YN370456 VER-155008 1134156-31-2

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

YN372253 MKT-077 147366-41-4

MKT-077 is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems.

YN370010 KNK437 218924-25-5

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

YN370455 Pifithrin-μ 64984-31-2

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.