YN330318 SC144 hydrochloride 917497-70-2

SC144 hydrochloride is the first-in-class orally active small-molecule gp130 inhibitor; inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 values in a submicromolar range.

YN330317 SC144 895158-95-9

SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of do...

YN330144 RCGD423 108237-91-8

RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation.