YN340120 Gandotinib

Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.

YN340120 Gandotinib 1229236-86-5

Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.

YN350251 Isoliquiritin apioside 120926-46-7

Isoliquiritin apioside, a component isolated fromGlycyrrhizae radix rhizome, significantly decreases PMA-induced increases inMMP9activities and suppresses PMA-induced activation ofMAPK and NF-κB. Isoliquiritin apioside...

YN371783 Tamoxifen Citrate 54965-24-1

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.

YN310360 Paris saponin VII 68124-04-9

Chonglou Saponin VII, a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

YN310285 Inauhzin 309271-94-1

Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.

YN373233 Cucurbitacin D 3877-86-9

Cucurbitacin D is an active component inCucurbita texana, disrupts interactions betweenHsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of t...

YN350155 Binimetinib 606143-89-9

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Phase 3.

YN350219 Honokiol 35354-74-6

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Phase 3.

YN350079 UM-164 903564-48-7

UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.

YN350097 BIX02188 334949-59-6

BIX02188 is a potentMEK5-selective inhibitor with an IC50 of 4.3nM. BIX02188 inhibitsERK5catalytic activity, with an IC50 of 810nM.

YN330482 Ethoxyquin 91-53-2

Ethoxyquin is an antioxidant used as a food preservative.

YN350227 Pachymic acid 29070-92-6

Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibitsAkt and ERKsignaling pathways.

YN350201 trans-Zeatin 1637-39-4

Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.

YN330608 1,3-Dicaffeoylquinic acid 19870-46-3

1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.