YN371041 HM03 500565-15-1

HM03 is a potent and selectiveHSPA5(Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity.

YN350097 BIX02188 334949-59-6

BIX02188 is a potentMEK5-selective inhibitor with an IC50 of 4.3nM. BIX02188 inhibitsERK5catalytic activity, with an IC50 of 810nM.

YN330337 Iguratimod 123663-49-0

Iguratimod is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.

YN330047 CU-CPT17e 2109805-75-4

CU-CPT17e is a potent multi-Toll-like receptor(TLR) agonist that activatesTLR3,TLR8, and TLR9.

YN330111 CU-CPT-8m 125079-83-6

CU-CPT-8m is a specificTLR8antagonist, with an IC50 of 67nM.

YN251429 Oridonin 28957-04-2

Oridonin (NSC-250682), a diterpenoid isolated fromRabdosia rubescens, acts as an inhibitor of Akt, with IC50s of 8.4 and 8.9μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory eff...

YN370232 Tanespimycin 75747-14-7

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Phase 2.

YN320539 BX471 217645-70-0

BX471 (ZK-811752) is an orally active, potent and selective non-peptideCCR1antagonist with a Ki of 1nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.