YN310146 PARP14 inhibitor H10 2084811-68-5

PARP14 inhibitor H10, compound H 10, is a selective inhibitor againstPARP14(IC50=490nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cellapoptosis.

YN310204 AZ6102 1645286-75-4

AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.

YN310223 AZD-2461 1174043-16-3

AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.