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YN360257 GSK1702934A 924377-85-5
GSK1702934A is a selectiveTRPC3agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.
MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.
YN310256 UPF 1069 1048371-03-4
UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.
YN320879 Ziprasidone 146939-27-7
Ziprasidone, an antipsychotic agent, is a combined5-HT (serotonin) and dopamine receptorantagonist. Ziprasidone has high affinity for rat (Ki: 3.4nM)/human (2.5nM) 5-HT1A receptors, 5-HT2A (0.42nM), and dopamine D2 receptor...
Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.
YN350047 Pluripotin 839707-37-8
Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP with Kd values of 98 nM and 212 nM respectively. It maintains embryonic stem cell (ESC) self-renewal.
YN373130 Wedelolactone 524-12-9
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
YN330001 Peretinoin 81485-25-8
Peretinoin is an oral acyclic retinoid retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such asretinoid X receptor(RXR) and retinoic acid receptor (RAR).
BX471 (ZK-811752) is an orally active, potent and selective non-peptideCCR1antagonist with a Ki of 1nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
YN320981 RS 504393 300816-15-3
RS 504393 is a selectiveCCR2chemokine receptor antagonist (IC50 values are 89nM and > 100μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).
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