YN340153 Napabucasin 83280-65-3

Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor.

YN340162 Homoharringtonine 26833-87-4

Homoharringtonine is a cytotoxic alkaloid, induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.

YN340075 C188-9 432001-19-9

C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.

YN340010 HJC0152 hydrochloride 1420290-99-8

HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.

YN340114 STAT3-IN-3 2361304-26-7

STAT3-IN-3 is a potent and selective inhibitor ofsignal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 inducesapoptosisin breast cancer cells. STAT3-IN-3 acts as a...

YN340274 Mogrol 88930-15-8

Mogrol is a biometabolite of mogrosides, and acts via inhibition of theERK1/2 and STAT3pathways, or reducingCREBactivation and activatingAMPKsignaling.

YN340005 HO-3867 1172133-28-6

HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.

YN340267 Corylifol A 775351-88-7

Corylifol A inhibits IL-6-inducedSTAT3activation and phosphorylation, with an IC50 of 0.81μM.

YN340257 Alantolactone 546-43-0

Alantolactone, a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction.

YN340256 Dihydroisotanshinone I 20958-18-3

Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.

YN340277 Tetramethylcurcumin 52328-97-9

Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation ofSTAT3by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflam...

YN340270 Cucurbitacin I 2222-07-3

Cucurbitacin I is a natural selective inhibitor of Jak2/STAT3, with potent anti-cancer activity.

YN330453 Balsalazide 80573-04-2

Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation...

YN340013 TPCA-1 507475-17-4

TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1.

YN340149 Stattic 19983-44-9

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.