YN321493 Ozagrel 82571-53-7

Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.

YN340284 Garcinone C 76996-27-5

Garcinone C, a xanthone derivative, is a natural compound extracted fromGarcinia oblongifolia Champthat is used as an anti-inflammatory, analgesia, astringency and granulation-promoting medicine, and has potential cytotoxic effects ...

YN310204 AZ6102 1645286-75-4

AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.

YN310321 MN-64 92831-11-3

MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.

YN310253 JW 55 664993-53-7

JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).

YN320056 VU0364770 61350-00-3

VU0364770 is a selective and potent positive allosteric modulator (PAM) ofmGlu4. VU0346770 exhibitsEC50s of 290nM and 1.1μM atrat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at m...

YN320759 Blonanserin 132810-10-7

Blonanserin (AD-5423) is a potent  and orally active5-HT2A(Ki=0.812nM) and dopamine D2 receptor(Ki=0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of...

YN330637 Negletein 29550-13-8

Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition ofTNF-α and IL-1βwith IC50 values of 1...

YN330562 Madecassic acid 18449-41-7

Madecassic acid, a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through a...

YN330436 Methylthiouracil 56-04-2

Methylthiouracil is an antithyroid preparation.

YN330612 β-Anhydroicaritin 38226-86-7

β-Anhydroicaritin is isolated fromBoswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties. β-Anhydroicaritin ameliorates the degrada...

YN330513 Ginsenoside Rc 11021-14-0

Ginsenoside Rc, one of major Ginsenosides fromPanax ginseng, enhances GABA receptorA(GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression ofTNF-α and IL-1β.

YN330569 Mulberroside A 102841-42-9

Mulberroside A is one of the main bioactive constituent in mulberry (Morus albaL.). Mulberroside A decreases the expressions ofTNF-α,IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and ...

YN360416 Vinpocetine 42971-09-5

Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

YN330576 Neochlorogenic acid 906-33-2

Neochlorogenic acid has outstanding antioxidant, antibacterial, antiviral, and antipyretic activities, it also exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. Neochlorogenic aci...