YN360257 GSK1702934A 924377-85-5

GSK1702934A is a selectiveTRPC3agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.

YN321640 Triprolidine hydrochloride mo... 6138-79-0

Triprolidine Hydrochloride is the hydrochloride salt form of Triprolidine, which is the first generation histamine H1 antagonist used in allergic rhinitis.

YN360394 ML204 hydrochloride 2070015-10-8

ML204 hydrochloride is a novel, potent, selectiveTRPC4/TRPC5channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, o...

YN321455 Mirtazapine 85650-52-8

Mirtazapine is an adrenergic and seroton receptor antagonist, used to treat depression.

YN360393 ML204 5465-86-1

ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectiv...

YN350142 VX-11e 896720-20-0

VX-11e is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.

YN321229 SCH-23390 hydrochloride 125941-87-9

SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selectivedopamine D1-like receptorantagonist with Kis of 0.2nM and 0.3nM for theD1 and D5receptor, respectively. SCH-23390 hydrochloride is a potent...

YN320361 Emedastine 87233-61-2

Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).

YN321522 Betahistine 5638-76-6

Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug.

YN360615 Rosiglitazone 122320-73-4

Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and...

YN321515 Brompheniramine maleate 980-71-2

Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist.

YN320432 L 888607 860033-06-3

L 888607 is a potent, and selectiveCRTH2(also known as DP2) agonist with a Ki of 0.8nM.

YN321508 Azelastine hydrochloride 79307-93-0

Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.

YN321530 Hydroxyzine dihydrochloride 2192-20-3

Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM.

YN321278 Laropiprant 571170-77-9

Laropiprant is a potent, selectiveDP receptorantagonist with Ki values of 0.57nM and 2.95nM for DP receptor and TP Receptor, respectively.