Genetic subtype-guided immunochemotherapy in diffuse large B cell lymphoma: The randomized GUIDANCE-01 trial Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases

The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19

Epitope editing enables targeted immunotherapy of acute myeloid leukaemia Primate gastrulation and early organogenesis at single-cell resolution Blebs promote cell survival by assembling oncogenic signalling hubs Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells Metabolic regulation of species-specific developmental rates Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

Enhanced T cell effector activity by targeting the Mediator kinase module Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin BTG1 mutation yields supercompetitive B cells primed for malignant transformation

Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9 Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology

Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells Heavy-chain CDR3-engineered B cells facilitate in vivo evaluation of HIV-1 vaccine candidates Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis

We need a genomics-savvy healthcare workforce Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial A H3K27M-targeted vaccine in adults with diffuse midline glioma Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Tissue morphology influences the temporal program of human brain organoid development Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1 Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease Seasonal light hours modulate peripheral clocks and energy metabolism in mice Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance

Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2 functions Transcriptomes and metabolism define mouse and human MAIT cell populations CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury Emergence and fate of stem cell–like Tcf7+ CD8+ T cells during a primary immune response to viral infection Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function

Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure Impaired intracellular Ca2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells A conserved mechanism for JNK-mediated loss of Notch function in advanced prostate cancer Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans