Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN420162 AICAR phosphate 681006-28-0
AICAR phosphate (Acadesine phosphate) is an adenosine analog and aAMPKactivator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR ph...
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
YN420164 Dorsomorphin 866405-64-3
Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JA...
YN420325 AMPK activator 1 1152423-98-7
AMPK activator 1 is anAMPKactivator extracted from patent WO2013116491A1, compound No.1-75, has an EC50 of <0.1μM.
YN420329 MT 63-78 1179347-65-9
MT 63-78 is a specific and potent directAMPKactivator with an EC50 of 25μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1pathw...
YN420071 Metformin D6 hydrochloride 1185166-01-1
Metformin D6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits themitochondrial respiratory chainin the liver, leading to activation ofAMPK, enhancing insulin sensitivity for type 2 diabe...
WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.
YN420163 Dorsomorphin dihydrochloride 1219168-18-9
Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, a...
MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.
EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.
YN420139 Ampkinone 1233082-79-5
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
O-304 (O-304X) is an orally available pan-activator of AMPK activated protein kinase (AMPK). O-304 (O-304X) exhibits a great potential as a novel drug to treat type 2 diabetes (T2D) and associated cardiovascular compl...
YN420227 YLF-466D 1273323-67-3
YLF-466D is a newly developedAMPKactivator, which inhibits platelet aggregation.
YN420313 3α-Hydroxymogrol 1343402-73-2
3α-Hydroxymogrol is a triterpenoid isolated fromSiraitia grosvenoriiSwingle, acts as a potentAMPKactivator, and enhances AMPK phosphorylation.
GSK621 is a specific and potent AMPK activator.
MK8722 is a potent and systemicpan-AMPKactivator.
IM156 (HL156A; HL271 acetate), a chemical derivative of Metformin (HY-B0627), is a potentAMPKactivator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model. IM156...
YN420044 PF-06409577 1467057-23-3
PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 ...
YN420121 HTH-01-015 1613724-42-7
HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.
ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer.
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