YN380070 DAPT 208255-80-5

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

YN380288 β-Amyloid (42-1), human 317366-82-8

β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). Amyloid β Peptide (42-1) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

YN380045 LX2343 333745-53-2

LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.

YN380002 Semagacestat 425386-60-3

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.

YN380301 β-Amyloid (4-10) 477284-32-5

β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model.

YN380127 Edonerpic maleate 519187-97-4

Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).

YN380046 4-(6-Bromo-2-benzothiazolyl)b... 566169-97-9

4-(6-Bromo-2-benzothiazolyl)benzenamine is aβ-amyloidPET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.

YN380139 Azeliragon 603148-36-3

Azeliragon (TTP488) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patien...

YN380307 β-Amyloid (33-40) 634204-57-2

β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.

YN380100 K 01-162 677746-25-7

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80nM.

YN380286 LPYFD-NH2 700361-48-4

LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation ofAβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease.

YN380057 PBD-150 790663-33-1

PBD-150 is a humanglutaminyl cyclase (hQC) Y115E-Y117Evariant inhibitor, with aKivalue of 490nM.

YN380027 BF 227 845647-80-5

BF 227 is a c and idate for an amyloid imaging probe for PET, with a Ki of 4.3nM forAβ1-42 fibrils.

YN380043 Aftin-4 866893-90-5

Aftin-4 is anAmyloid-β42(Aβ42) inducer.

YN380019 Anle138b 882697-00-9

Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-bar...

YN380135 FPS-ZM1 945714-67-0

FPS-ZM1 is a high-affinityRAGEinhibitor with a Ki of 25nM.

YN380136 amyloid P-IN-1 1819986-22-5

amyloid P-IN-1 is used in the research of diseases or disorders wherein depletion of serum amyloid P component (SAP), including amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.

YN380048 Glutaminyl Cyclase Inhibito... 2110449-60-8

Glutaminyl Cyclase Inhibitor 1 is aglutaminyl cyclaseinhibitor with an IC50 of 0.5μM.