Gastric mucin
Cat. No. :YN251413
CAS No. :84082-64-4
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order@ubiochem.com| Product Name: | Gastric mucin |
| CAS NO.: | 84082-64-4 |
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| Molecular Weight: | NA |
| Molecular Formula: | NA |
| SMILES: | NA |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma.In Vitro:Gastric mucin may be integrally involved in the mechanism of gastric mucosal injury caused by Helicobacter pylori leading to gastritis, peptic ulceration, and possibly gastric cancer. Gastric mucins are classified into two types based on their histochemical properties. The first is a surface mucous cell-type mucin, secreted from the surface mucous cells. The second is found in deeper portions of the mucosa and is secreted by gl and mucous cells, including mucous neck cells, cardiac gl and cells, and pyloric gl and cells. The unique O-glycans in gastric mucin appears to function as a natural antibiotic, protecting the host fromH. pyloriinfection. Gastric mucin may provide protection to the surface epithelium gastrointestinal tract by scavenging oxidants produced within the lumen; however, it does so at the expense of its viscoelastic properties. Both native and pronase-treated mucin effectively scavenge hydroxyl radical and that the scavenging properties are not significantly different. The effective concentration of mucin required for a 50% reduction in malondialdehyde production is 10 mg/mL for both native and pronase-treated mucin. |
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