Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN440345 Tirabrutinib hydrochloride 1439901-97-9
ONO-4059 (GS-4059) is highly potent and selective BTK inhibitor with an IC50 of 2.2 nM.
QL47, a broad-spectrumantiviralagent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor ofBTKwith an IC50 of 7nM .
YN440118 Vecabrutinib 1510829-06-7
Vecabrutinib (SNS-062) is a potent, noncovalentBTK and ITKinhibitor, withKdvalues of 0.3nM and 2.2nM, respectively. Vecabrutinib shows an IC50 of 24nM forITK.
YN440134 Ibrutinib D5 1553977-17-5
Ibrutinib D5 (PCI-32765 D5) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor.
YN440041 Btk inhibitor 2 1558036-85-3
Btk inhibitor 2 is a BTK inhibitor.
PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase(BTK), with an IC50 of 1.3nM.
YN440008 Ibrutinib-biotin 1599432-18-4
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02nM for BTK.
YN440031 (±)-Zanubrutinib 1633350-06-7
(±)-Zanubrutinib ((±)-BGB-3111) is a potent, selective and orally availableBruton's tyrosine kinase (Btk)inhibitor.
YN440048 BMS-986142 1643368-58-4
BMS-986142 is a potent and highly selective reversible inhibitor ofBruton's tyrosine kinase(BTK) with an IC50 of 0.5nM.
YN440230 Orelabrutinib 1655504-04-3
Orelabrutinib is a potent, orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). Orelabrutinib has potential antineoplastic activity.
YN440032 Zanubrutinib 1691249-45-2
Zanubrutinib (BGB-3111) is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR.
YN440229 Remibrutinib 1787294-07-8
Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. R...
BIIB068 is a potent, selective, reversible and orally activeBTKinhibitor with an IC50 of 1nM and aKdof 0.3nM. BIIB068 shows more >400-fold selective forBTKthan other kinases. BIIB068 has the potential for autoimmu...
YN440150 Branebrutinib 1912445-55-6
Branebrutinib (BMS-986195) is a highly potent, selective covalent, irreversible inhibitor of Bruton’s tyrosine kinase(BTK), with an IC50 of 0.1nM.
ARQ 531 is a reversible non-covalent inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT BTK and C481S BTK, respectively
Acalabrutinib(ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has impro...
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