Remibrutinib
Cat. No. :YN440229
CAS No. :1787294-07-8
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order@ubiochem.com| Product Name: | Remibrutinib |
| CAS NO.: | 1787294-07-8 |
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| Molecular Weight: | 507.53 |
| Molecular Formula: | C₂₇H₂₇F₂N₅O₃ |
| SMILES: | O=C(NC1=CC(F)=CC(C2=NC=NC(N)=C2OCCN(C)C(C=C)=O)=C1C)C3=CC=C(C4CC4)C=C3F |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases. |
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