SCH00013
Cat. No. :YN480084
CAS No. :217963-18-3
86-020-82000279
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order@ubiochem.com| Product Name: | SCH00013 |
| CAS NO.: | 217963-18-3 |
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| Molecular Weight: | 324.38 |
| Molecular Formula: | C₁₈H₂₀N₄O₂ |
| SMILES: | N#CC1=CC=C(C(O)CN2CC=C(C(CC3)=NNC3=O)CC2)C=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4. In vitro: SCH00013 at 10-4 M increased the systolic cell shortening by 52% above the base-line value in association with an insignificant increase in the systolic fluorescence ratio by 15% above the control. In vivo: The positive inotropic effects of 10?4 M SCH00013 on the dog and rabbit were 38% and 29% of the maximal response to isoproterenol. CH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs. SCH00013 elicits a positive inotropic effect mainly through an increase in myofilament Ca2+ sensitivity without increasing the heart rate. . |
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