(3S,5R)-Rosuvastatin
Cat. No. :YN360630
CAS No. :1242184-42-4
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5mg
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Product Name: | (3S,5R)-Rosuvastatin |
CAS NO.: | 1242184-42-4 |
Chemical Name: | |
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Molecular Weight: | 481.54 |
Molecular Formula: | C₂₂H₂₈FN₃O₆S |
SMILES: | O=C(O)C[C@@H](O)C[C@@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2 |
Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
Transportation: | Room temperature in continental US; may vary elsewhere. |
Description: | (3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoAreductase inhibitor with an IC50 of 11nM. Rosuvastatin potently blockshuman ether-a-go-go related gene (hERG)current with an IC50 of 195nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. |
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