R 80123
Cat. No. :YN370077
CAS No. :133718-30-6
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order@ubiochem.com| Product Name: | R 80123 |
| CAS NO.: | 133718-30-6 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 459.54 |
| Molecular Formula: | C₂₆H₂₉N₅O₃ |
| SMILES: | O=C(N(C1CCCCC1)C)CO/N=C(C2=CC=CC=C2)C3=CC4=C(N=C(NC(C5)=O)N5C4)C=C3 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone). In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure.With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. . |
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| References: |
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