PF-543 Citrate
Cat. No. :YN320986
CAS No. :1415562-83-2
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order@ubiochem.com| Product Name: | PF-543 Citrate |
| CAS NO.: | 1415562-83-2 |
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| Molecular Weight: | 657.73 |
| Molecular Formula: | C₃₃H₃₉NO₁₁S |
| SMILES: | OC(C(O)=O)(CC(O)=O)CC(O)=O.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=C2)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitiveSPHK1inhibitor with an IC50 of 2nM and a Ki of 3.6nM. PF-543 Citrate is >100-fold selectivity forSPHK1over SPHK2. PF-543 Citrate is an effective potent inhibitor ofsphingosine 1-phosphate (S1P)formation in whole blood with an IC50 of 26.7nM. PF-543 Citrate inducesapoptosis, necrosis, and autophagy . |
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